HYPERGENES Project meeting

• Haifa (ISRAEL), March 3rd-4th 2010

HYPERGENES Project meeting

• Milan (ITALY), October 10th-11th 2009

HYPERGENES Project meeting

• Leuven (BELGIUM), May 4th-5th 2009

HYPERGENES Clinicians meeting

• Berlin (GERMANY), June 19th 2008

HYPERGENES Kickoff meeting

• Milan (ITALY), February 4th-5th 2008

References

• O Mayer, J Filipovsk�, M Pe�ta, R C�fkov�, M Dolej�ov� and J �imon "Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffnessAng II, eNOS and arterial stiffness" Journal of Human Hypertension 22, 111-118 (February 2008) | doi:10.1038/sj.jhh.1002279,
• O. MAYER JR., J. FILIPOVSK�, M. PE�TA, R. C�FKOV�, M. DOLEJ�OV�, J. �IMON "The Interaction of Endothelial Nitric Oxide Synthase Polymorphism and Current Smoking in Terms of Increased Arterial Stiffness" Physiol. Res. 59: 529-536, 2010
• Jan Filipovsky "Genetic determinants of arterial properties and of heart disease" Artery Research (2010) 4, 128-130
• Berthonneche C, Peter B, Schupfer F, Hayoz P, Kutalik Z, et al. (2009) Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains. PLoS ONE 4(8): e6610. doi:10.1371/journal.pone.0006610
• Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, et al. (2009) Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet 5(6): e1000504. doi:10.1371/journal.pgen.1000504
• Pillas D, Hoggart CJ, Evans DM, O�Reilly PF, Sipila K, et al. (2010) Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy. PLoS Genet 6(2): e1000856. doi:10.1371/journal.pgen.1000856
• Geneletti et al.: Assessing causal relationships in genomics: From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs. Emerging Themes in Epidemiology 2011 8:5. doi:10.1186/1742-7622-8-5
• Boger CA, Gorski M, Li M, Hoffmann MM, Huang C, et al. (2011) Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genet 7(9): e1002292. doi:10.1371/journal.pgen.1002292
• Mayer Jr O, Filipovsk� J, Pe�ta M, C�fkov� R, Dolej�ov� M, Simon J. The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness. Physiol Res. 2010; 59: 529-36.
• Filipovsk� J, Mayer Jr O, Dolej�ov� M, Seidlerov� J. The assessment of carotid-femoral distance for aortic pulse wave velocity: Should it be estimated from body height? Artery Research 2010; 4: 19-23.
• Filipovsk� J. Genetic determinants of arterial properties and of heart disease. Artery Research 2010; 4: 128-130.
• R Kosoy, M Ransom, H Chen, M Marconi, F Macciardi, N Glorioso, PK Gregersen, D Cusi and MF Seldin "Evidence for malaria selection of a CR1 haplotype in Sardinia", Genes and Immunity (2011), 1�7, Macmillan Publishers Limited
• Potkin SG, Turner JA, Guffanti G, Lakatos A, Torri F, Keator DB, Macciardi F. Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations. Cogn Neuropsychiatry. 2009;14(4-5):391-418.PMID: 19634037
• Potkin SG, Guffanti G, Lakatos A, Turner JA, Kruggel F, Fallon JH, Saykin AJ, Orro A, Lupoli S, Salvi E, Weiner M, Macciardi F; Alzheimer's Disease Neuroimaging Initiative. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS One. 2009 Aug 7;4(8):e6501
• Volpi L, Roversi G, Colombo EA, Leijsten N, Concolino D, Calabria A, Mencarelli MA, Fimiani M, Macciardi F, Pfundt R, Schoenmakers EF, Larizza L. Targeted nextgeneration sequencing appoints c16orf57 as clericuzio-type poikiloderma with neutropenia gene. Am J Hum Genet. 2010 Jan;86(1):72-6. Epub 2009 Dec 10
• Bianchi S, Burla A, Conti C, Farkash A, Kent C, Maman Y, Shabo A. Biomedical data integration - capturing similarities while preserving disparities. Conf Proc IEEE Eng Med Biol Soc. 2009;1:4654-7
• Kalatzis FG, Giannakeas N, Exarchos TP, Lorenzelli L, Adami A, Decarli M, Lupoli S, Macciardi F, Markoula S, Georgiou I, Fotiadis DI. Developing a genomic-based point-of-care diagnostic system for rheumatoid arthritis and multiple sclerosis. Conf Proc IEEE Eng Med Biol Soc. 2009;1:827-30
• Wizner B, Dechering DG, Thijs L, Kuznetsova T, Richart T, Jin Y, Gasowski J, O’Brien E, Struijker-Boudier HA, Grodzicki T, Staessen JA. Conventional and 24-hour ambulatory blood pressure as independent predictors of elastic arterial properties. Blood Pressure Monitoring 2009; 14: 12-19. (February 2009)
• Bochud M, Staessen JA, Maillard M, Mazeko MJ, Kuznetsova T, Woodiwiss A, Richart T, Norton G, Thijs L, Elston R, Burnier M. Ethnic differences in proximal and distal tubular sodium reabsorption are heritable in Black and White populations. Journal of Hypertension 2009; 27: 606-612. (March 2009)
• Jin Y, Kuznetsova T, Maillard M, Richart T, Thijs L, Bochud M, Herreggods MC, Burnier M, Fagard R, Staessen JA. Independent relations of left ventricular structure with 24-h urinary excretion of sodium and aldosterone. Hypertension 2009; 54: 489-495. (March 2009)
• Dechering D, Wisner B, Adiyaman A, Nawrot T, Jin Y, Richart T, Kuznetsova T, Struijker-Boudier HA, Thien T, Staessen JA. Sphygmomanometric and ambulatory blood pressures as forerunners of carotid and femoral intima-media thickness. Journal of Hypertension 2009; 27: 813-821. (April 2009)
• Adiyaman A, Dechering D, Thien T, Boggia J, Li Y, Wang JG, Hansen TW, O’Brien E, Richart T, Thijs L, Staessen JA. Response to “Determinants of the ambulatory arterial stiffness index regression line.” Hypertension 2009; 53: e34. (May 2009) Kuznetsova T, Herbots L, Jin Y, Staessen JA. Early systolic and diastolic left ventricular dysfunction in hypertensive heart disease. Health Care Bulletin 2009; spring edition: 46-49.
• M'buyamba-Kabangu JR, Biswika RT, Thijs L, Tshimanga GM, Ngalula FM, Disashi T, Kayembe PK, Richart T, M'buyamba-Kayamba JR, Lepira FB, Staessen JA. In-hospital mortality among black patients admitted for hypertension-related disorders in Mbuji Mayi, Congo. American Journal of Hypertension 2009; 22: 643-648. (June 2009)
• Cagliani R, Fumagalli M, Pozzoli U, Riva S, Comi GP, Torri F, Macciardi F, Bresolin N, Sironi M. Diverse evolutionary histories for beta-adrenoreceptor genes in humans. Am J Hum Genet. 2009;85(1):64-75. Epub 2009 Jul 2.PMID: 19576569. (July 2009)
• Tikhonoff V, Zhang H, Richart T, Staessen JA. Blood pressure as a prognostic factor after acute stroke. Lancet Neurol. 2009; 8: 938-48. (September 2009)
• Kuznetsova T, Manunta P, Casamssima N, Messaggio E, Jin Y, Thijs L, Richart T, Fagard RH, Bianchi G, Staessen JA. Left ventricular geometry and endogenous ouabain in a Flemish population. Journal of Hypertension 2009; 27: 1884-1891. (September 2009)
• Ferrandi M, Cusi D, Molinari I, Del Vecchio L, Barlassina C, Rastaldi MP, Schena FP, Macciardi F, Marcantoni C, Roccatello D, Peters LL, Armelloni S, Min L, Giardino L, Mattinzoli D, Camisasca C, Palazzo F, Manunta P, Ferrari P, Bianchi G. alpha- and beta- Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy. J Mol Med (2010); 88:203–217 (published online October 2009)
• Richart T, Kuznetsova T, Wizner B, Struijker-Boudier HA, Staessen JA. Validation of automated oscillometric versus manual measurement of the ankle-brachial index. Hypertension Research 2009; 32: 884-888. (October 2009)
• Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type-2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2009; published on-line Nov, 12. (November 2009)
• Strazzullo P, D’Elia L, Kandala N-B, Cappuccio FP. Salt intake, stroke and cardiovascular disease: a meta-analysis of prospective studies. Br Med J 2009; 339: b4567; published online Nov, 25. (November 2009)
• Liu L, Wang Z, Gong L, Zhang Y, Thijs L, Staessen JA, Wang J. Blood pressure lowering for the secondary prevention of stroke: a Chinese trial and a systematic review of the literature. Hypertension Research 2009; 32: 1032-1040. (December 2009)
• Adriano Chio, Jennifer C. Schymick, Gabriella Restagno, Sonja W. Scholz, Federica Lombardo, Shiao-Lin Lai, Gabriele Mora, Hon-Chung Fung, Angela Britton, Sampath Arepalli, J. Raphael Gibbs, Michael Nalls, Stephen Berger, Lydia Coulter Kwee, Eugene Z. Oddone, Jinhui Ding, Cynthia Crews, Ian Rafferty, Nicole Washecka, Dena Hernandez, Luigi Ferrucci, Stefania Bandinelli, Jack Guralnik, Fabio Macciardi, Federica Torri, Sara Lupoli, Stephen J. Chanock, Gilles Thomas, David J. Hunter, Christian Gieger, H. Erich Wichmann, Andrea Calvo, Roberto Mutani, Stefania Battistini, Fabio Giannini, Claudia Caponnetto, Giovanni Luigi Mancardi, Vincenzo La Bella, Francesca Valentino, Maria Rosaria Monsurr�, Gioacchino Tedeschi, Kalliopi Marinou, Mario Sabatelli, Amelia Conte, Jessica Mandrioli, Patrizia Sola, Fabrizio Salvi, Ilaria Bartolomei, Gabriele Siciliano, Cecilia Carlesi, Richard W. Orrell, Kevin Talbot, Zachary Simmons, James Connor, Erik P. Pioro, Travis Dunkley, Dietrich A. Stephan, Dalia Kasperaviciute, Elizabeth M. Fisher, Sibylle Jabonka, Michael Sendtner, Marcus Beck, Lucie Bruijn, Jeffrey Rothstein, Silke Schmidt, Andrew Singleton, John Hardy and Bryan J. Traynor "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis" Human Molecular Genetics, 2009, Vol. 18, No. 8 p. 1524-1532 doi:10.1093/hmg/ddp059 Advance Access published on February 4, 2009
• Benaglio P, Rivolta C, 2010 Ultra High Throughput Sequencing in Human DNA Variation Detection: A Comparative Study on the NDUFA3-PRPF31 Region. PLoS ONE 5(9): e13071. doi:10.1371/journal.pone.0013071
• Cusi D., Macciardi F., Conti P. "HYPERGENES: la Commissione Europea finanzia un network internazionale per identificare i geni dell'ipertensione" published on "Management della Sanit�" on March, 3 2008
• Filigheddu F, Argiolas G, Bulla E, Troffa C, Bulla P, Fadda S, Zaninello R, Degortes S, Frau F, Pitzoi S, Glorioso N. Clinical variables, not RAAS polymorphisms, predict blood pressure response to ACE inhibitors in Sardinians. Pharmacogenomics. 2008; 9:1419-27.
• Tikhonoff V, Staessen JA, Kuznetsova T, Thijs L, Hasenkamp S, Blumer V, Stolarz K, Seidlerova J, Filipovsky J, Nikitin Yu, Peleska J, Kawecka-Jaszcz K; Casiglia E, Brand-Herrmann SM, Brand E, for the European Project On Genes in Hypertension (EPOGH investigators). SAH gene variants revisited in the European Project On Genes in Hypertension. Journal of Hypertension 2008; 26: 244-250.
• Ivanov S., Ryabikov A., Malyutina S. Arterial stiffness and pulse wave reflection in relation with hypertension. Bulletin SB RAMS 2008;3 (131): 9-12 (in Russian).
• Mazdorova E.V. The associations of polymorphism of candidate genes of cardiovascular diseases with atherosclerotic lesion of carotid wall. Bulletin SB RAMS 2008;4 (132): 65-71 (Issue for young researchers� publications; in Russian).
• Staessen JA, Kuznetsova T, Zhang H, Maillard M, Bochud M, Hasenkamp S, Westerkamp J, Richart T, Thijs L, Li X, Brand-Herrmann SM, Burnier M, Brand E. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. Hypertension 2008; 51: 1643-1650.
• Jin Y, Kuznetsova T, Tikhonoff V, Maillard M, Bochud M, Burnier M, Hasenkamp S, Brand E, Brand-Herrmann SM, Richart T, Staessen JA. egmental renal sodium handling in relation to the human SAH gene. Hypertension 2008; 52:e12-e13.
• Nawrot TS, Van Hecke E, Thijs L, Richart T, Kuznetsova T, Jin Y, Vangronsveld J, Roels HA, Staessen JA. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmetally exposed population. Environmental Health Perspectives 2008; 116: 1620-1628.
• Wizner B, Dechering DG, Thijs L, Atkins N, Fagard R, O�Brien E, de Leeuw PW, Parati G, Palatini P, Clement D, Grodzicki T, Kario K, Staessen JA. Short-term and long-term reproducibility of the morning blood pressure in older patients with isolated systolic hypertension. Journal of Hypertension 2008; 26: 1328-1335.
• Hansen TW, Thijs L, Boggia J, Li Y, Kikuya M, Bj�rklund-Bodeg�rd K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Lind L, Sandoya E, Imai Y, Wang J, Ibsen H, O�Brien E, Staessen JA. Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations. Hypertension 2008; 52: 229-235.
• Gasowski J, Li Y, Kuznetsova T, Richart T, Thijs L, Grodzicki T, Clarke T, Staessen JA. Is "usual" blood pressure a proxy for 24-hour ambulatory blood pressure in predicting cardiovascular outcomes? American Journal of Hypertension 2008; 21: 994-1000.
• Tikhonoff V, Hasenkamp S, Kuznetsova T, Thijs L, Jin Y, Richart T, Zhang H, Brand-Herrmann SH, Brand E, Casiglia E, Staessen JA. Blood pressure and metabolic phenotypes in relation to the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms in a White population. Journal of Human Hypertension 2008; 22: 864-867.
• Seidlerov� J, Staessen JA, Nawrot T, Brand E, Brand-Herrmann SM, Casamassima N, Citterio L, Hasenkamp S, Kuznetsova T, Li Y, Manunta P, Richart T, Struijker-Boudier HA, Fagard R, Filipovsk� J. Arterial properties in relation to genetic variations in -adducin and the renin-angiotensin system in a White population. Journal of Human Hypertension 2008; 23: 55-64.
• Tikhonoff V, Kuznetsova T, Stolarz-Skrzypek K, Richart T, Kawecka-Jaszcz K, Casiglia E, Staessen JA. Modulation of genetic cardiovascular risk by age and lifestyle. Current Cardiovascular Risk Reports 2008; 2: 398-404.
• Dechering DG, van der Steen MS, Adiyaman A, Thijs L, Deinum J, Li Y, Dolan E, Akkermans RPM, Richart T, Hansen TW, Kikuya M, Wang J, O�Brien E, Thien T, Staessen JA. Reproducibility of the ambulatory arterial stiffness index in hypertensive patients. Journal of Hypertension 2008; 26: 1993-2000.
• Adiyaman A, Dechering DG, Boggia J, Li Y, Hansen TW, Kikuya M, Bj�rklund-Bodeg�rd K, Richart T, Thijs L, Torp-Pedersen C, Ohkubo T, Dolan E, Imai Y, Sandoya E, Ibsen H, Wang J, Lind L, O�Brien E, Thien T, Staessen JA, on behalf of the International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators. Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations. Hypertension 2008; 52: 1038-1044.
• Seidlerov� J, Staessen JA, Bochud M, Nawrot T, Casamassima N, Citterio L, Kuznetsova T, Jin Y, Manunta P, Richart T, Struijker-Boudier HA, Fagard R, Filipovsk� J, Bianchi G. Arterial properties in relation to genetic variations in the adducin subunits in a white population. American Journal of Hypertension 2008; 22: 21-26.
• Jin Y, Kuznetsova T, Tikhonoff V, Thijs L, Hasenkamp S, B�umer V, Stolarz K, Ryabikov A, Richart T, Malyutina S, Nikitin Y, Casiglia E, Kawecka-Jaszcz K,Olszanecka A, Brand-Herrmann S-M, Brand E, Fagard R, Staessen JA. Left ventricular structure in relation to the human SAH gene in the European Project on Genes in Hypertension. Hypertension Research 2009; 32: 145-151.
• Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, Nguyen DD, Mathalon D, Ford J, Lauriello J, Macciardi F; FBIRN: A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull. 2009 Jan;35(1):96-108.
• Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, Macciardi F: Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol Psychiatry. 2008 Dec 9. doi: 10.1038/mp.2008.127 [Epub ahead of print]
• S. Bianchi, A. Burla, C. Conti, A. Farkash, C. Kent, Y. Maman, A. Shabo: "From Data to Knowledge: Semantic Warehousing of Diverse Health Information" presented to Next Generation Information Technologies and Systems: NGITS 2009.
• Salvi E., Guffanti G., Orro A., Torri F., Lupoli S., Turner J., Keator D., Fallon J., Potkin S., Barlassina C., Cusi D. ,Milanesi L. , Macciardi F: "Comparison of different methods to estimate genetic ancestry and control for stratification in genome-wide association studies", presented to the European Society Human Genetics (Barcelona, May 31st - June 3rd, 2008), and awarded as the best oral presentation.
• Orro A, Guffanti G, Salvi E, Macciardi F, Milanesi L. SNPLims: a data management system for genome wide association studies. BMC BIOINFORMATICS 2008: 9;S13,s2
• di Giuseppe R, de Lorgeril M, Salen P, Laporte F, Di Castelnuovo A, Krogh V, Siani A, Arnout J, Cappuccio FP, van Dongen M, Donati MB, de Gaetano G, Iacoviello L on behalf of the European Collaborative Group of the IMMIDIET Project. Alcohol drinking and n-3 polyunsaturated fatty acids in healthy men and women from three European populations. Am J Clin Nutr 2009; 89: 354-62
• Latella MC, Di Castelnuovo A, de Lorgeril M, Arnout J, Cappuccio FP, Krogh V, Siani A, van Dongen M, Donati MB, de Gaetano G, Iacoviello L on behalf of the European Collaborative Group of the IMMIDIET Project.. Genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors: results from the IMMIDIET Study. Atherosclerosis 2009; in press
• Miller MA, McTernan PG, Harte AL, da Silva NF, Strazzullo P, Alberti KGMM, Kumar S, Cappuccio FP. Circulating endotoxin levels: a novel marker of cardiovascular and metabolic risk in a British multi-ethnic population. Atherosclerosis 2009; 203(2): 494-502
• Miller MA, Strazzullo P, Karanam S, Cappuccio FP. Ethnic variation in levels of circulating IgG autoantibodies to oxidised low-density lipoprotein. Atherosclerosis 2009; 203(1): 126-36
• Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani NJ, Dominiczak AF, Connell JM, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe PB. Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS ONE 2009;4(4):e5003
• Arcari A, Zito F, Di Castelnuovo A, de Curtis A, Dirckx C, Arnout J, Cappuccio FP, van Dongen MCJM, de Lorgeril M, Krogh V, Siani A, Donati MB, de Gaetano G, Iacoviello L on behalf of the European Collaborative Group of the IMMIDIET Project. Hs-CRP is strongly associated with anthropometric variables in three European populations at different risk of cardiovascular disease: results from the IMMIDIET project. J Thromb Haemost 2008; 6:436-43
• Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Webster J, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio FP, Ji C, Iacone R, Strazzullo P, Moley KH, Cheeseman C. SLC2A9 is a high capacity urate transporter in humans. PLoS Med 2008; 5(10):e197 (1509-23)
• Costanzo S, Di Castelnuovo A, Zito F, Krogh V, Siani A, Arnout J, Cappuccio FP, Miller MA, van Dongen M, de Lorgeril M, de Gaetano G, Donati MB, Iacoviello L on behalf of the European Collaborative Group of the IMMIDIET Project. Prevalence, awareness, treatment and control of hypertension in three European populations at different risk of coronary heart disease. Report from the Immidiet Project. J Hypertension 2008; 26: 2303-11
• Galletti F, D'Elia L, Barba G, Siani A, Cappuccio FP, Farinaro E, IAcone R, Russo O, De Palma D, Ippolito R, Strazzullo P. High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eight-year follow-up study. J Clin Endocrinol Metab 2008; 93: 3922-6
• Russo P, Siani A, Miller MA, Karanam S, Esposito T, Gianfrancesco F, Barba G, Lauria F, Strazzullo P, Cappuccio FP. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. Arterioscl Thromb Vasc Biol 2008;28: 1569-74